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Subretinal injection damage has implication for experimental control and treatment in rat model of retinopathy of prematurity
In their 2017 article, “Effect of subretinal injection on retinal structure and function in a rat oxygen-induced retinopathy model,” Becker et al used the Phoenix MICRON IV fundus camera, Phoenix MICRON OCT2 and corresponding layer analysis software Insight 2D, and the Phoenix MICRON focal ERG to find that subretinal injection of saline or even introduction of a needle into the vitreal space has a detrimental effect on a rat model of retinopathy of prematurity. In normal adult rats, there is no effect of subretinal injections (results in other species vary) so these rats with oxygen-induced retinopathy may be more sensitive to damage.
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